The infection of Helicobacter is associated with a variety of gastro-intestinal diseases, such as stomach ulcer, chronic active gastritis and gastric, duodenal and gastric adenocarcinoma. Antibodies to Helicobacter are developed in individuals infected with helicobacter as a serological response. Detecting these specific antibodies to helicobacter can be use as a qualitative assay in the diagnosis of helicobacter infection.